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Applied Genomics: An Introduction to Bioinformatics and Network Modeling G23.1130 Kenneth Birnbaum and Mark Siegal Fall 2008 This course will introduce fundamental methods of analyzing large data sets from genomics experiments. Through a combination of lectures, hands-on computational training, and in-depth discussions of current scientific papers, students will learn the conceptual foundations of basic analytical methods, the computational skills to implement these methods, and the reasoning skills to read critically the primary literature in genomics. Analysis will focus on data from genome-wide studies of gene expression using microarrays and from genome-wide studies of molecular interactions. Methods covered will include clustering, multiple-hypothesis testing, and network inference. The course will also be open to advanced undergraduates by permission of the instructors. A large part of the course is dedicated to students completing an individual project that will be tailored to meet their background and training. |
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MAP Natural Science II: Genomes and Diversity V55.0314 Mark Siegal next offered Spring 2010 Millions of species of animals, plants and microbes inhabit our planet. Genomics, the study of all the genes in an organism, is providing new insights into this amazing diversity of life on Earth. We begin with the fundamentals of DNA, genes and genomes. We then explore microbial diversity, with an emphasis on how genomics can reveal many aspects of organisms, from their ancient history to their physiological and ecological habits. We follow with examinations of animal and plant diversity, focusing on domesticated species, such as dogs and tomatoes, as examples of how genomic methods can be used to identify genes that underlie new or otherwise interesting traits. Genomics has also transformed the study of human diversity and human disease. We examine the use of DNA to trace human ancestry, as well as the use of genomics as a diagnostic tool in medicine. With the powerful new technologies to study genomes has come an increased power to manipulate them. We conclude by considering the societal implications of this ability to alter the genomes of crop plants, livestock and potentially humans. |